Article
Cortisol Stress Response in Men and Women Modulated Differentially by the Mu-Opioid Receptor Gene Polymorphism OPRM1 A118G.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Oct 2015
Lovallo William R, Enoch Mary-Anne, Acheson Ashley, Cohoon Andrew J, Sorocco Kristen H, Hodgkinson Colin A, Vincent Andrea S, Glahn David C, Goldman David
Abstract excerpt
Differences in stress reactivity may affect long-term health outcomes, but there is little information on how these differences arise. The stress axis is regulated by, in part, the endogenous opioid, beta-endorphin, acting on mu-opioid receptors. Persons carrying one or two copies of the G allele of the mu-opioid receptor gene (OPRM1 A118G) may have higher receptor binding for beta-endorphin compared with AA...
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