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Article

The mu-opioid receptor polymorphism A118G predicts cortisol responses to naloxone and stress.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jan 2006

Chong Rachel Y, Oswald Lynn, Yang Xiaoju, Uhart Magdalena, Lin Ping-I, Wand Gary S

Abstract excerpt

A polymorphism in the mu-opioid receptor (MOR) (A118G) has been shown to increase beta-endorphin binding affinity, theoretically placing greater inhibitory tone on hypothalamic corticotropin-releasing hormone (CRH) neurons. We hypothesized that the minor allele (G) would predict cortisol responses to both pharmacological (naloxone) and psychological (stress) activation of the hypothalamic-pituitary-adrenal (HPA)...

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Source

Identifiers

PMID: 16123758
DOI: 10.1038/sj.npp.1300856

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CRH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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