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Article

Association between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the mu-opioid receptor locus (OPRM1).

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Apr 2003

Hernandez-Avila Carlos A, Wand Gary, Luo Xingguang, Gelernter Joel, Kranzler Henry R

Abstract excerpt

UNLABELLED: This study examined whether a reportedly functional polymorphism in the gene encoding the mu-opioid receptor protein (A118G, which causes an Asn40Asp substitution in the receptor's extracellular domain), modifies the cortisol response to the opioid antagonist naloxone. The polymorphism occurs commonly in European Americans and some other population groups, underscoring its potential phenotypic...

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Source

Identifiers

PMID: 12627468
DOI: 10.1002/ajmg.b.10054

Genes

OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the mu-opioid receptor locus (OPRM1).PMID 12627468Read ↗

Population-specific effects of the Asn40Asp polymorphism at the mu-opioid receptor gene (OPRM1) on HPA-axis activation.Semantic proximity Read ↗

The mu-opioid receptor gene polymorphism (A118G) alters HPA axis activation induced by opioid receptor blockade.Semantic proximity Read ↗

Role of the HPA axis and the A118G polymorphism of the mu-opioid receptor in stress-induced drinking behavior.Semantic proximity Read ↗

The mu-opioid receptor polymorphism A118G predicts cortisol responses to naloxone and stress.Semantic proximity Read ↗

Altered levels of basal cortisol in healthy subjects with a 118G allele in exon 1 of the Mu opioid receptor gene.Semantic proximity Read ↗

Cortisol Stress Response in Men and Women Modulated Differentially by the Mu-Opioid Receptor Gene Polymorphism OPRM1 A118G.Semantic proximity Read ↗

Mu-opioid receptor A118G polymorphism in healthy volunteers affects hypothalamic-pituitary-adrenal axis adrenocorticotropic hormone stress response to metyrapone.Semantic proximity Read ↗

A functional polymorphism of the mu-opioid receptor gene (OPRM1) influences cue-induced craving for alcohol in male heavy drinkers.Semantic proximity Read ↗

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OPRM1 gene variation influences hypothalamic-pituitary-adrenal axis function in response to a variety of stressors in rhesus macaques.Semantic proximity Read ↗

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