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Article

OPRM1 gene variation influences hypothalamic-pituitary-adrenal axis function in response to a variety of stressors in rhesus macaques.

Psychoneuroendocrinology - 1 Oct 2011

Schwandt Melanie L, Lindell Stephen G, Higley James D, Suomi Stephen J, Heilig Markus, Barr Christina S

Abstract excerpt

The endogenous opioid system is involved in modulating a number of behavioral and physiological systems, including the hypothalamic-pituitary-adrenal (HPA) axis. In humans, a functional variant in the OPRM1 gene (OPRM1 A118G) is associated with a number of outcomes, including attenuated HPA axis responses to stress. A nonsynonymous variant (OPRM1 C77G) in the rhesus macaque has been shown to have similar effects...

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Source

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Identifiers

PMID: 21459516
DOI: 10.1016/j.psyneuen.2011.03.002
PMCID: PMC3131436

Genes

OPRM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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