Article
Altered levels of basal cortisol in healthy subjects with a 118G allele in exon 1 of the Mu opioid receptor gene.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Oct 2006
Bart Gavin, LaForge K Steven, Borg Lisa, Lilly Charles, Ho Ann, Kreek Mary Jeanne
Abstract excerpt
The mu opioid receptor is centrally involved in the development of the addictive diseases. It also modulates the stress responsive hypothalamic-pituitary-adrenal axis. Receptors encoded by the variant 118G polymorphism in exon 1 of the mu opioid receptor gene have a threefold increase in beta-endorphin binding and beta-endorphin is three times more potent in receptor-mediated activation of G protein-coupled...
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