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Article

The mu-opioid receptor gene polymorphism (A118G) alters HPA axis activation induced by opioid receptor blockade.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jan 2002

Wand Gary S, McCaul Mary, Yang Xioaju, Reynolds Joanna, Gotjen Deidre, Lee Shing, Ali Ahmed

Abstract excerpt

An A118G nucleotide exchange in exon 1 of the mu-opioid receptor causes an Asn40Asp substitution polymorphism in the receptor's extracellular domain. In vitro studies show that the Asp40 variant of the mu-opioid receptor binds beta-endorphin three times more avidly than the more common Asn40 variant. Paraventricular corticotropin releasing hormone neurons, which activate the HPA axis, express mu-opioid receptors...

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Identifiers

PMID: 11751037
DOI: 10.1016/S0893-133X(01)00294-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The mu-opioid receptor gene polymorphism (A118G) alters HPA axis activation induced by opioid receptor blockade.PMID 11751037Read ↗

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