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Article

NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma.

Nature communications - 16 Apr 2015

Wilson C L, Jurk D, Fullard N, Banks P, Page A, Luli S, Elsharkawy A M, Gieling R G, Chakraborty J Bagchi, Fox C, Richardson C, Callaghan K, Blair G E, Fox N, Lagnado A, Passos J F, Moore A J, Smith G R, Tiniakos D G, Mann J, Oakley F, Mann D A

Abstract excerpt

Hepatocellular carcinoma (HCC) develops on the background of chronic hepatitis. Leukocytes found within the HCC microenvironment are implicated as regulators of tumour growth. We show that diethylnitrosamine (DEN)-induced murine HCC is attenuated by antibody-mediated depletion of hepatic neutroph...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25879839
DOI: 10.1038/ncomms7818
PMCID: PMC4410629

Genes

HDAC1
CXCL1
CXCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25879839-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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