Article

Splenic granulopoiesis and S100A9 drive resistance to checkpoint inhibitors conferred by liver metastases

2025-10-01

Abstract excerpt

Here, we investigate why liver metastases reduce the efficacy of immune checkpoint inhibitors (CPI). The poor prognosis of patients with liver metastases is associated with a systemic increase in neutrophils. Using experimental models, we confirm that mice with liver metastases respond poorly to CPI, have elevated neutrophils and suppress the response of subcutaneous lesions to CPI. We demonstrate that liver metas...

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Identifiers and source

Literature Corpus work: b8d102b1-f2cb-51e0-8186-89e9a85836a9
DOI: 10.1101/2025.09.30.679035

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