Establishment and Characterization of the Murine Liver Tumor Cell Line ΔCN60 with Conditional Caspase-8 and IKKγ/NEMO Inactivation and a Hepatocyte-Biliary Progenitor-like Phenotype.

Abstract excerpt

Caspase-8 and the NF-κB essential modulator (NEMO, also referred to as IKKγ) play critical roles in controlling TNF-α-induced cell death and survival in hepatocytes. The aim of this study was to generate a hepatocyte-derived cell line in which the Casp8 and Nemo genes can be conditionally inactivated simultaneously to investigate the significance of the corresponding signaling pathways. To this end, we induced...

Topics

Join the communities discussing this publication.

• Caspase 8
• Cell Proliferation
• Hepatocytes
• I-kappa B Kinase
• Intracellular Signaling Peptides and Proteins