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Article

Role of imbalance between neutrophil elastase and alpha 1-antitrypsin in cancer development and progression.

The Lancet. Oncology - 1 Mar 2004

Sun Zhifu, Yang Ping

Abstract excerpt

Neutrophil elastase and alpha 1-antitrypsin are a pair of protease and protease inhibitor counterparts. The imbalance between the two counterparts is generally thought to cause tissue damage, which could create a favourable tissue environment for carcinogens and tumour progression. Laboratory research and clinical findings have indicated that a deficiency in alpha1-antitrypsin is associated with increased risk of...

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PMID: 15003202
DOI: 10.1016/S1470-2045(04)01414-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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