Distinct histopathological phenotypes of severe alcoholic hepatitis suggest different mechanisms driving liver injury and failure.

doi:10.1172/JCI157780

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Article

Distinct histopathological phenotypes of severe alcoholic hepatitis suggest different mechanisms driving liver injury and failure.

The Journal of clinical investigation - 15 Jul 2022

Ma Jing, Guillot Adrien, Yang Zhihong, Mackowiak Bryan, Hwang Seonghwan, Park Ogyi, Peiffer Brandon J, Ahmadi Ali Reza, Melo Luma, Kusumanchi Praveen, Huda Nazmul, Saxena Romil, He Yong, Guan Yukun, Feng Dechun, Sancho-Bru Pau, Zang Mengwei, Cameron Andrew MacGregor, Bataller Ramon, Tacke Frank, Sun Zhaoli, Liangpunsakul Suthat, Gao Bin

Abstract excerpt

Intrahepatic neutrophil infiltration has been implicated in severe alcoholic hepatitis (SAH) pathogenesis; however, the mechanism underlying neutrophil-induced injury in SAH remains obscure. This translational study aims to describe the patterns of intrahepatic neutrophil infiltration and its involvement in SAH pathogenesis. Immunohistochemistry analyses of explanted livers identified two SAH phenotypes despite a...

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PMID: 35838051
DOI: 10.1172/JCI157780
PMCID: PMC9282929

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