Article

CXCR2 inhibition enables NASH-HCC immunotherapy

2022-02-25

Abstract excerpt

<h4>Objective</h4> Hepatocellular carcinoma (HCC) is increasingly associated with non-alcoholic steatohepatitis (NASH). HCC immunotherapy offers great promise; however, recent data suggests NASH-HCC may be less sensitive to conventional immune checkpoint inhibition (ICI). We hypothesised that targeting neutrophils using a CXCR2 small molecule inhibitor may sensitise NASH-HCC to ICI therapy. <h4>Design</h4> Neutr...

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Literature Corpus work: 16a39b81-1c7c-56e3-b377-484d4dd5cc3a
DOI: 10.1101/2022.02.24.481779

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