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Article

Toll-like receptor 4 activity protects against hepatocellular tumorigenesis and progression by regulating expression of DNA repair protein Ku70 in mice.

Hepatology (Baltimore, Md.) - 1 May 2013

Wang Ziyan, Yan Jun, Lin Heng, Hua Fang, Wang Xiaoxing, Liu Hanzhi, Lv Xiaoxi, Yu Jiaojiao, Mi Su, Wang Jiaping, Hu Zhuo-Wei

Abstract excerpt

UNLABELLED: Hepatocellular carcinoma (HCC) is a devastating consequence of chronic inflammatory liver diseases. The goal of this study was to investigate whether Toll-like receptor 4 (TLR4) activity contributes to HCC initiation and progression in mice. A mouse model of diethylnitrosamine (DEN)-induced HCC was generated with wild-type and TLR4 mutant mice, and the development and progression of HCC and senescent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23299825
DOI: 10.1002/hep.26234

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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