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Article

Nuclear factor-kappaB1 (p50) limits the inflammatory and fibrogenic responses to chronic injury.

The American journal of pathology - 1 Mar 2005

Oakley Fiona, Mann Jelena, Nailard Sarah, Smart David E, Mungalsingh Narendra, Constandinou Christothea, Ali Shakir, Wilson Susan J, Millward-Sadler Harry, Iredale John P, Mann Derek A

Abstract excerpt

In this study we addressed the role of the nuclear factor (NF)-kappaB1/p50 subunit in chronic injury of the liver by determining the inflammatory and fibrotic responses of nfkappab1-null mice in an experimental model that mimics chronic liver disease. Mice received repeated hepatic injuries throughout 12 weeks by intraperitoneal injection of the hepatotoxin carbon tetrachloride. In response nfkappab1(-/-) mice...

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Identifiers

PMID: 15743782
DOI: 10.1016/s0002-9440(10)62291-2
PMCID: PMC1602348

Genes

TNF
HDAC1
ICAM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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