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Article

Defective apoptotic cell contractility provokes sterile inflammation, leading to liver damage and tumour suppression.

eLife - 19 Apr 2021

Julian Linda, Naylor Gregory, Wickman Grant R, Rath Nicola, Castino Giovanni, Stevenson David, Bryson Sheila, Munro June, McGarry Lynn, Mullin Margaret, Rice Alistair, Del Río Hernández Armandodel, Olson Michael F

Abstract excerpt

Apoptosis is characterized by profound morphological changes, but their physiological purpose is unknown. To characterize the role of apoptotic cell contraction, ROCK1 was rendered caspase non-cleavable (ROCK1nc) by mutating aspartate 1113, which revealed that ROCK1 cleavage was necessary for forceful contraction and membrane blebbing. When homozygous ROCK1nc mice were treated with the liver-selective apoptotic...

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Identifiers

PMID: 33871359
DOI: 10.7554/eLife.61983
PMCID: PMC8087448

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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