Article
Genome-wide search followed by replication reveals genetic interaction of CD80 and ALOX5AP associated with systemic lupus erythematosus in Asian populations.
Annals of the rheumatic diseases - 1 May 2016
Zhang Yan, Yang Jing, Zhang Jing, Sun Liangdan, Hirankarn Nattiya, Pan Hai-Feng, Lau Chak Sing, Chan Tak Mao, Lee Tsz Leung, Leung Alexander Moon Ho, Mok Chi Chiu, Zhang Lu, Wang Yongfei, Shen Jiangshan Jane, Wong Sik Nin, Lee Ka Wing, Ho Marco Hok Kung, Lee Pamela Pui Wah, Chung Brian Hon-Yin, Chong Chun Yin, Wong Raymond Woon Sing, Mok Mo Yin, Wong Wilfred Hing Sang, Tong Kwok Lung, Tse Niko Kei Chiu, Li Xiang-Pei, Avihingsanon Yingyos, Rianthavorn Pornpimol, Deekajorndej Thavatchai, Suphapeetiporn Kanya, Shotelersuk Vorasuk, Ying Shirley King Yee, Fung Samuel Ka Shun, Lai Wai Ming, Wong Chun-Ming, Ng Irene Oi Lin, Garcia-Barcelo Maria-Merce, Cherny Stacey S, Cui Yong, Sham Pak Chung, Yang Sen, Ye Dong-Qing, Zhang Xue-Jun, Lau Yu Lung, Yang Wanling
Abstract excerpt
OBJECTIVES: Genetic interaction has been considered as a hallmark of the genetic architecture of systemic lupus erythematosus (SLE). Based on two independent genome-wide association studies (GWAS) on Chinese populations, we performed a genome-wide search for genetic interactions contributing to SLE susceptibility. METHODS: The study involved a total of 1 659 cases and 3 398 controls in the discovery stage and...
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