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Article

Variants in TNFSF4, TNFAIP3, TNIP1, BLK, SLC15A4 and UBE2L3 interact to confer risk of systemic lupus erythematosus in Chinese population.

Rheumatology international - 1 Apr 2014

Zuo Xian-Bo, Sheng Yu-Jun, Hu Su-Juan, Gao Jin-Ping, Li Yang, Tang Hua-Yang, Tang Xian-Fa, Cheng Hui, Yin Xian-Yong, Wen Lei-Lei, Sun Liang-Dan, Yang Sen, Cui Yong, Zhang Xue-Jun

Abstract excerpt

Our previous genome-wide association studies on SLE have identified several susceptibility genes involved in NF-κB signaling pathway, including TNFSF4, TNFAIP3, TNIP1, BLK, SLC15A4 and UBE2L3. The aim of this study is to investigate the association model (additive, dominant, recessive) of these genes and search for possible gene-gene interactions between them. In this study, we explored the association model of...

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PMID: 24091983
DOI: 10.1007/s00296-013-2864-3

Genes

TNFSF4
TNIP1
BLK
TNFAIP3

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Variants in TNFSF4, TNFAIP3, TNIP1, BLK, SLC15A4 and UBE2L3 interact to confer risk of systemic lupus erythematosus in Chinese population.PMID 24091983Read ↗

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Gene-gene interaction of BLK, TNFSF4, TRAF1, TNFAIP3, and REL in systemic lupus erythematosus.Semantic proximity Read ↗

Synergistic activation of NF-κB by TNFAIP3 (A20) reduction and UBE2L3 (UBCH7) augment that synergistically elevate lupus risk.Semantic proximity Read ↗

Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: a case-control association study.Semantic proximity Read ↗

Replicated associations of TNFAIP3, TNIP1 and ETS1 with systemic lupus erythematosus in a southwestern Chinese population.Semantic proximity Read ↗

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.Semantic proximity Read ↗

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