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Article

Follow-up study identifies two novel susceptibility loci PRKCB and 8p11.21 for systemic lupus erythematosus.

Rheumatology (Oxford, England) - 1 Apr 2011

Sheng Yu-Jun, Gao Jin-Ping, Li Jian, Han Jian-Wen, Xu Qiang, Hu Wen-Long, Pan Ting-Meng, Cheng Yi-Lin, Yu Ze-Ying, Ni Cheng, Yao Sha, He Cai-Feng, Liu Yang-Sheng, Li Yun, Ge Hong-Mei, Xiao Feng-Li, Sun Liang-Dan, Yang Sen, Zhang Xue-Jun

Abstract excerpt

OBJECTIVE: We have performed a large-scale replication study based on our previous genome-wide association study (GWAS) of SLE in the Chinese Han population to further explore additional genetic variants affecting susceptibility to SLE. METHODS: Thirty-eight single nucleotide polymorphisms from our GWAS were genotyped in two additional Chinese Han cohorts (total 3152 cases and 7050 controls) using the Sequenom...

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Source

Identifiers

PMID: 21134959
DOI: 10.1093/rheumatology/keq313

Genes

PRKCB
IKBKB
DKK4

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