Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus.

doi:10.1002/art.33354

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Article

Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus.

Arthritis and rheumatism - 1 Feb 2012

Hughes Travis, Adler Adam, Kelly Jennifer A, Kaufman Kenneth M, Williams Adrienne H, Langefeld Carl D, Brown Elizabeth E, Alarcón Graciela S, Kimberly Robert P, Edberg Jeffrey C, Ramsey-Goldman Rosalind, Petri Michelle, Boackle Susan A, Stevens Anne M, Reveille John D, Sanchez Elena, Martín Javier, Niewold Timothy B, Vilá Luis M, Scofield R Hal, Gilkeson Gary S, Gaffney Patrick M, Criswell Lindsey A, Moser Kathy L, Merrill Joan T, Jacob Chaim O, Tsao Betty P, James Judith A, Vyse Timothy J, Alarcón-Riquelme Marta E, Harley John B, Richardson Bruce C, Sawalha Amr H

Abstract excerpt

OBJECTIVE: Several confirmed genetic susceptibility loci for lupus have been described. To date, no clear evidence for genetic epistasis in lupus has been established. The aim of this study was to test for gene-gene interactions in a number of known lupus susceptibility loci. METHODS: Eighteen single-nucleotide polymorphisms tagging independent and confirmed lupus susceptibility loci were genotyped in a set of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21952918
DOI: 10.1002/art.33354
PMCID: PMC3268866

Genes

CTLA4
ITGAM
PDCD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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