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Article

Single-cell mutational profiling and clonal phylogeny in cancer.

Genome research - 1 Dec 2013

Potter Nicola E, Ermini Luca, Papaemmanuil Elli, Cazzaniga Giovanni, Vijayaraghavan Gowri, Titley Ian, Ford Anthony, Campbell Peter, Kearney Lyndal, Greaves Mel

Abstract excerpt

The development of cancer is a dynamic evolutionary process in which intraclonal, genetic diversity provides a substrate for clonal selection and a source of therapeutic escape. The complexity and topography of intraclonal genetic architectures have major implications for biopsy-based prognosis and for targeted therapy. High-depth, next-generation sequencing (NGS) efficiently captures the mutational load of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24056532
DOI: 10.1101/gr.159913.113
PMCID: PMC3847780

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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