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Article

Polymorphisms of the thiopurine S-methyltransferase gene among the Libyan population.

The Libyan journal of medicine - 1 Jan 2015

Zeglam Hamza Ben, Benhamer Abdrazak, Aboud Adel, Rtemi Haitem, Mattardi Meftah, Saleh Saleh Suleiman, Bashein Abdullah, Enattah Nabil

Abstract excerpt

BACKGROUND: Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that catalyses the S-methylation of 6-mercaptopurine and azathioprine. Low activity phenotypes are correlated with polymorphism in the TPMT gene. Patients with low or undetectable TMPT activity could develop severe myelosuppression when they are treated with standard doses of thiopurine drugs. Since ethnic differences in the TPMT gene...

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Identifiers

PMID: 25819542
DOI: 10.3402/ljm.v10.27053
PMCID: PMC4376936

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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