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Article

TPMT genetic variations in populations of the Russian Federation.

Pediatric blood & cancer - 1 Feb 2009

Samochatova Elena V, Chupova Natalia V, Rudneva Anastassia, Makarova Olga, Nasedkina Tatyana V, Fedorova Olga E, Glotov Andrei S, Kozhekbaeva Zh, Maiorova Olga A, Roumyantsev Alexander G, Krynetski Eugene Y, Krynetskaia Natalia F, Evans William E, Ribeiro Raul C

Abstract excerpt

BACKGROUND: Polymorphisms that reduce the activity of thiopurine S-methyltransferase (TPMT) cause adverse reactions to conventional doses of thiopurines, routinely used for antileukemic and immunosuppressive treatment. There are more than 20 variant alleles of TPMT that cause decreased enzymatic activity. We studied the most common variant alleles of TPMT and their frequency distribution in a large cohort of...

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Identifiers

PMID: 19034904
DOI: 10.1002/pbc.21837
PMCID: PMC2794198

Genes

TPMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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