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Article

Molecular analysis of the thiopurine S-methyltransferase alleles in Bolivians and Tibetans.

Journal of clinical pharmacy and therapeutics - 1 Oct 2005

Lu H-F, Shih M-C, Hsueh S-C, Chen C-M, Chang J-Y, Chang J-G

Abstract excerpt

BACKGROUND: Thiopurine drugs are used as immunosuppressant or cytotoxic drugs. Thiopurine S-methyltransferase (TPMT) methylates and thereby modulates the therapeutic and toxic effects of these drugs. The activity of TPMT is affected by genetic polymorphism of TPMT alleles, and these alleles have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16164497
DOI: 10.1111/j.1365-2710.2005.00640_1.x

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16164497-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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