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Article

Frequency of thiopurine S-methyltransferase genetic variation in Thai children with acute leukemia.

Medical and pediatric oncology - 1 Oct 2000

Hongeng S, Sasanakul W, Chuansumrit A, Pakakasama S, Chattananon A, Hathirat P

Abstract excerpt

BACKGROUND: Thiopurine S-methyltransferase (TPMT) catalyzes the S-methylation (inactivation) of mercaptopurine, azathioprine, and thioguanine, and exhibits genetic variation. About 11% of Caucasians have intermediate TPMT activity because of heterozygosity, and about 1 in 300 inherits TPMT deficiency as an autosomal codominant trait. If patients who have intermediate or deficient TPMT activity receive the...

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Source

Identifiers

PMID: 11025471
DOI: 10.1002/1096-911x(20001001)35:4<410::aid-mpo3>3.0.co;2-r

Genes

TPMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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