Article
Phenotyping and genotyping study of thiopurine S-methyltransferase in healthy Chinese children: a comparison of Han and Yao ethnic groups.
British journal of clinical pharmacology - 1 Aug 2004
Zhang Jian-ping, Guan Yong-yuan, Wu Jue-heng, Xu An-long, Zhou Shufeng, Huang Min
Abstract excerpt
AIMS: Ethnicity is an important variable influencing drug response. Thiopurine S-methyltransferase (TPMT) plays an important role in the metabolism of thiopurine drugs. Previous population studies have identified ethnic variations in both phenotype and genotype of TPMT, but limited information is available within Chinese population that comprises at least 56 ethnic groups. The current study was conducted to...
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