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Article

[Thiopurine S-methyltransferase gene polymorphism in Chilean blood donors].

Revista medica de Chile - 1 Feb 2009

Alvarez L Luis, Venegas S Mauricio, Larrondo L Milton, Becerra B Natalia, Castro L Ariel, Quera P Rodrigo

Abstract excerpt

BACKGROUND: Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that catalyzes the S-methylation of 6-mercaptopurine and azathioprine. Low-activity phenotypes are correlated with polymorphism in the TPMT gene. Patients with low or undetectable TMPT activity could develop severe myelosuppression when they are treated with standard doses of thiopurine drugs. Since ethnic differences in the TPMT gen...

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Source

Identifiers

PMID: 19543639
DOI: /S0034-98872009000200001

Genes

TPMT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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