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Article

Site-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response.

Science signaling - 24 Mar 2015

Hein Kerstin, Mittler Gerhard, Cizelsky Wiebke, Kühl Michael, Ferrante Francesca, Liefke Robert, Berger Ina M, Just Steffen, Sträng J Eric, Kestler Hans A, Oswald Franz, Borggrefe Tilman

Abstract excerpt

Physiologically, Notch signal transduction plays a pivotal role in differentiation; pathologically, Notch signaling contributes to the development of cancer. Transcriptional activation of Notch target genes involves cleavage of the Notch receptor in response to ligand binding, production of the Notch intracellular domain (NICD), and NICD migration into the nucleus and assembly of a coactivator complex....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25805888
DOI: 10.1126/scisignal.2005892

Genes

CARM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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