Article
Tyrosine phosphorylation of CARM1 promotes its enzymatic activity and alters its target specificity.
Nature communications - 22 Apr 2024
Itonaga Hidehiro, Mookhtiar Adnan K, Greenblatt Sarah M, Liu Fan, Martinez Concepcion, Bilbao Daniel, Rains Masai, Hamard Pierre-Jacques, Sun Jun, Umeano Afoma C, Duffort Stephanie, Chen Chuan, Man Na, Mas Gloria, Tottone Luca, Totiger Tulasigeri, Bradley Terrence, Taylor Justin, Schürer Stephan, Nimer Stephen D
Abstract excerpt
An important epigenetic component of tyrosine kinase signaling is the phosphorylation of histones, and epigenetic readers, writers, and erasers. Phosphorylation of protein arginine methyltransferases (PRMTs), have been shown to enhance and impair their enzymatic activity. In this study, we show that the hyperactivation of Janus kinase 2 (JAK2) by the V617F mutation phosphorylates tyrosine residues (Y149 and Y334)...
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