Article
The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis.
Development (Cambridge, England) - 15 Jul 2015
Liu Zhenyi, Brunskill Eric, Varnum-Finney Barbara, Zhang Chi, Zhang Andrew, Jay Patrick Y, Bernstein Irv, Morimoto Mitsuru, Kopan Raphael
Abstract excerpt
Although Notch1 and Notch2 are closely related paralogs and function through the same canonical signaling pathway, they contribute to different outcomes in some cell and disease contexts. To understand the basis for these differences, we examined in detail mice in which the Notch intracellular domains (N1ICD and N2ICD) were swapped. Our data indicate that strength (defined here as the ultimate number of...
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