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Article

Transcriptional Mechanisms by the Coregulator MAML1

17 Oct 2009

Abstract excerpt

The Mastermind-like (MAML) proteins are transcriptional coactivators for Notch signaling, an evolutionarily conserved pathway that plays several key roles in development and in human disease. The MAML family contains MAML1, MAML2, and MAML3. More recently, MAML1 has been shown to function as a coactivator for the tumor suppressor p53, the MADS box transcription enhancer factor (MEF) 2C, and beta-catenin. In...

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PMID: 19751190
DOI: 10.2174/138920309789630543

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