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Article

Evidence that C promoter-binding factor 1 binding is required for Notch-1-mediated repression of activator protein-1.

The Journal of biological chemistry - 26 Mar 2004

Chu Jianlin, Bresnick Emery H

Abstract excerpt

Cell fate determination in invertebrate and vertebrate systems is regulated by the Notch signaling pathway. Four mammalian Notch genes, Notch 1-4, encode differentially expressed transmembrane receptors. The canonical Notch pathway involves proteolytic liberation of the Notch-1 intracellular domain (NIC-1), which activates CSL (CBF1, Su(H), and Lag-1)-mediated transactivation. We showed previously that NIC-1 also...

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PMID: 14645224
DOI: 10.1074/jbc.M311510200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Evidence that C promoter-binding factor 1 binding is required for Notch-1-mediated repression of activator protein-1.PMID 14645224Read ↗

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Characterization of CSL (CBF-1, Su(H), Lag-1) mutants reveals differences in signaling mediated by Notch1 and Notch2.Semantic proximity Read ↗

Identification of a Paralog-Specific Notch1 Intracellular Domain Degron.Semantic proximity Read ↗

MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.Semantic proximity Read ↗

OPTHiS Identifies the Molecular Basis of the Direct Interaction between CSL and SMRT Corepressor.Semantic proximity Read ↗

The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis.Semantic proximity Read ↗

Structure-function analysis of RBP-J-interacting and tubulin-associated (RITA) reveals regions critical for repression of Notch target genes.Semantic proximity Read ↗

Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling.Semantic proximity Read ↗

SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function.Semantic proximity Read ↗

Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1.Semantic proximity Read ↗

Functional Replacement of the Intracellular Region of the Notch1 Receptor by Epstein-Barr Virus Nuclear Antigen 2Semantic proximity Read ↗

Differential effects of Drosophila mastermind on asymmetric cell fate specification and neuroblast formation.Semantic proximity Read ↗

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