Article
Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes.
Nature methods - 1 May 2015
Hasenberg Anja, Hasenberg Mike, Männ Linda, Neumann Franziska, Borkenstein Lars, Stecher Manuel, Kraus Andreas, Engel Daniel R, Klingberg Anika, Seddigh Pegah, Abdullah Zeinab, Klebow Sabrina, Engelmann Swen, Reinhold Annegret, Brandau Sven, Seeling Michaela, Waisman Ari, Schraven Burkhart, Göthert Joachim R, Nimmerjahn Falk, Gunzer Matthias
Abstract excerpt
Neutrophil granulocyte biology is a central issue of immunological research, but the lack of animal models that allow for neutrophil-selective genetic manipulation has delayed progress. By modulating the neutrophil-specific locus Ly6G with a knock-in allele expressing Cre recombinase and the fluorescent protein tdTomato, we generated a mouse model termed Catchup that exhibits strong neutrophil specificity....
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