Article
The loss of RGS protein-Gα(i2) interactions results in markedly impaired mouse neutrophil trafficking to inflammatory sites.
Molecular and cellular biology - 1 Nov 2012
Cho Hyeseon, Kamenyeva Olena, Yung Sunny, Gao Ji-Liang, Hwang Il-Young, Park Chung, Murphy Philip M, Neubig Richard R, Kehrl John H
Abstract excerpt
Neutrophils are first responders rapidly mobilized to inflammatory sites by a tightly regulated, nonredundant hierarchy of chemoattractants. These chemoattractants engage neutrophil cell surface receptors triggering heterotrimeric G-protein Gα(i) subunits to exchange GDP for GTP. By limiting the duration that Gα(i) subunits remain GTP bound, RGS proteins modulate chemoattractant receptor signaling. Here, we show...
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