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A transgenic zebrafish line for in vivo visualisation of neutrophil myeloperoxidase

19 Apr 2019

Abstract excerpt

The neutrophil enzyme myeloperoxidase (MPO) is a major enzyme made by neutrophils to generate antimicrobial and immunomodulatory compounds, notably hypochlorous acid (HOCl), amplifying their capacity for destroying pathogens and regulating inflammation. Despite its roles in innate immunity, the importance of MPO in preventing infection is unclear, as individuals with MPO deficiency are asymptomatic with the...

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Share to Immune Response and Inflammation
Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Share to Nitric Oxide and Endothelin Effects

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PMID: 31002727
DOI: 10.1371/journal.pone.0215592

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