Article
Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow.
The Journal of experimental medicine - 21 Oct 2013
Devi Sapna, Wang Yilin, Chew Weng Keong, Lima Ronald, A-González Noelia, Mattar Citra N Z, Chong Shu Zhen, Schlitzer Andreas, Bakocevic Nadja, Chew Samantha, Keeble Jo L, Goh Chi Ching, Li Jackson L Y, Evrard Maximilien, Malleret Benoit, Larbi Anis, Renia Laurent, Haniffa Muzlifah, Tan Suet Mien, Chan Jerry K Y, Balabanian Karl, Nagasawa Takashi, Bachelerie Françoise, Hidalgo Andrés, Ginhoux Florent, Kubes Paul, Ng Lai Guan
Abstract excerpt
Blood neutrophil homeostasis is essential for successful host defense against invading pathogens. Circulating neutrophil counts are positively regulated by CXCR2 signaling and negatively regulated by the CXCR4-CXCL12 axis. In particular, G-CSF, a known CXCR2 signaler, and plerixafor, a CXCR4 antagonist, have both been shown to correct neutropenia in human patients. G-CSF directly induces neutrophil mobilization...
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