Article

Human neutrophil development and functionality are enabled in a humanized mouse model

2022-02-25

Abstract excerpt

Mice with a functional human immune system serve as an invaluable tool to study the development and function of human immune system in vivo. A major technological limitation of all current humanized mouse models is the lack of mature and functional human neutrophils in circulation and tissues. To overcome this, we generated a humanized mouse model named MISTRGGR, in which the mouse granulocyte colony stimulating f...

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Literature Corpus work: 7018cdf4-2b08-5ba7-9cc3-be56ce8000aa
DOI: 10.1101/2022.02.25.481352

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