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The Gp1ba-Cre transgenic mouse: a new model to delineate platelet and leukocyte functions

15 Nov 2018

Abstract excerpt

Abstract Conditional knockout (KO) mouse models are invaluable for elucidating the physiological roles of platelets. The Platelet factor 4-Cre recombinase (Pf4-Cre) transgenic mouse is the current model of choice for generating megakaryocyte/platelet-specific KO mice. Platelets and leukocytes work closely together in a wide range of disease settings, yet the specific contribution of platelets to these processes...

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PMID: 30429161
DOI: 10.1182/blood-2018-09-877787

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