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Article

Flavaglines Stimulate Transient Receptor Potential Melastatin Type 6 (TRPM6) Channel Activity.

PloS one - 1 Jan 2015

Blanchard Maxime G, de Baaij Jeroen H F, Verkaart Sjoerd A J, Lameris Anke L, Basmadjian Christine, Zhao Qian, Désaubry Laurent, Bindels René J M, Hoenderop Joost G J

Abstract excerpt

Magnesium (Mg2+) is essential for enzymatic activity, brain function and muscle contraction. Blood Mg2+ concentrations are tightly regulated between 0.7 and 1.1 mM by Mg2+ (re)absorption in kidney and intestine. The apical entry of Mg2+ in (re)absorbing epithelial cells is mediated by the transient receptor potential melastatin type 6 (TRPM6) ion channel. Here, flavaglines are described as a novel class of...

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Identifiers

PMID: 25774985
DOI: 10.1371/journal.pone.0119028
PMCID: PMC4361557

Genes

TRPM6

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Flavaglines Stimulate Transient Receptor Potential Melastatin Type 6 (TRPM6) Channel Activity.PMID 25774985Read ↗

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