Article

Insulin receptor substrate 4 deficiency mediates the insulin effect on the epithelial magnesium channel TRPM6 and causes hypomagnesemia

2022-10-04

Abstract excerpt

<h4>ABSTRACT</h4> The kidney is the key regulator of magnesium (Mg 2+ ) homeostasis in the human body. In the distal convoluted tubule (DCT), the apical epithelial magnesium (Mg 2+ ) channel TRPM6, determines how much Mg 2+ is excreted in the urine. To better understand the regulation of human renal Mg 2+ absorption we identified novel, potential interaction partners of TRPM6 by pursuing a liquid chromatograp...

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Literature Corpus work: 070e4670-c76a-5513-8022-d99e49d5c397
DOI: 10.1101/2022.10.01.510479

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