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Article

Role of the alpha-kinase domain in transient receptor potential melastatin 6 channel and regulation by intracellular ATP.

The Journal of biological chemistry - 18 Jul 2008

Thébault Stéphanie, Cao Gang, Venselaar Hanka, Xi Qi, Bindels René J M, Hoenderop Joost G J

Abstract excerpt

Transient receptor potential melastatin 6 (TRPM6) plays an essential role in epithelial Mg(2+) transport. TRPM6 and its closest homologue, TRPM7, both combine a cation channel with an alpha-kinase domain. However, the role of this alpha-kinase domain in TRPM6 channel activity remains elusive. The aim of this study was to investigate the regulation of TRPM6 channel activity by intracellular ATP and the involvement...

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Share to Adenosine Triphosphate
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18490453
DOI: 10.1074/jbc.M800167200

Genes

TRPM6
TRPM7

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Role of the alpha-kinase domain in transient receptor potential melastatin 6 channel and regulation by intracellular ATP.PMID 18490453Read ↗

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