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Article

TRPM6 kinase activity regulates TRPM7 trafficking and inhibits cellular growth under hypomagnesic conditions.

Cellular and molecular life sciences : CMLS - 1 Dec 2014

Brandao Katherine, Deason-Towne Francina, Zhao Xiaoyun, Perraud Anne-Laure, Schmitz Carsten

Abstract excerpt

The channel kinases TRPM6 and TRPM7 are both members of the melastatin-related transient receptor potential (TRPM) subfamily of ion channels and the only known fusions of an ion channel pore with a kinase domain. TRPM6 and TRPM7 form functional, tetrameric channel complexes at the plasma membrane by heteromerization. TRPM6 was previously shown to cross-phosphorylate TRPM7 on threonine residues, but not vice...

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Source

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Identifiers

PMID: 24858416
DOI: 10.1007/s00018-014-1647-7
PMCID: PMC4234683

Genes

TRPM6
TRPM7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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TRPM6 kinase activity regulates TRPM7 trafficking and inhibits cellular growth under hypomagnesic conditions.PMID 24858416Read ↗

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