Article
Methionine sulfoxide reductase B1 (MsrB1) recovers TRPM6 channel activity during oxidative stress.
The Journal of biological chemistry - 20 Aug 2010
Cao Gang, Lee Kyu Pil, van der Wijst Jenny, de Graaf Mark, van der Kemp Annemiete, Bindels René J M, Hoenderop Joost G J
Abstract excerpt
Mg(2+) is an essential ion for many cellular processes, including protein synthesis, nucleic acid stability, and numerous enzymatic reactions. Mg(2+) homeostasis in mammals depends on the equilibrium between intestinal absorption, renal excretion, and exchange with bone. The transient receptor potential melastatin type 6 (TRPM6) is an epithelial Mg(2+) channel, which is abundantly expressed in the luminal...
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