Article
Common single nucleotide polymorphisms in transient receptor potential melastatin type 6 increase the risk for proton pump inhibitor-induced hypomagnesemia: a case-control study.
Pharmacogenetics and genomics - 1 Mar 2017
Hess Mark W, de Baaij Jeroen H F, Broekman Mark M T J, Bisseling Tanya M, Haarhuis Bertram J T, Tan Adriaan C I T L, Te Morsche René H M, Hoenderop Joost G J, Bindels René J M, Drenth Joost P H
Abstract excerpt
OBJECTIVE: Proton pump inhibitors (PPIs) are effective drugs for the treatment of gastric acid-related disorders. Serious adverse events are rare for PPIs, but recent data suggest that PPIs cause hypomagnesemia. The aim of this study was to estimate the frequency of PPI-induced hypomagnesemia and to define the risk factors for its development. MATERIALS AND METHODS: A total of 133 chronic users of PPIs were...
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