Article
Transient receptor potential melastatin 6 knockout mice are lethal whereas heterozygous deletion results in mild hypomagnesemia.
Nephron. Physiology - 1 Jan 2011
Woudenberg-Vrenken Titia E, Sukinta Arjaree, van der Kemp Annemiete W, Bindels René J M, Hoenderop Joost G J
Abstract excerpt
BACKGROUND: Hypomagnesemia with secondary hypocalcemia is due to disturbed renal and intestinal magnesium (Mg(2+)) (re)absorption. The underlying defect is a mutation in the transient receptor potential melastatin type 6 (TRPM6), a Mg(2+)-permeable ion channel expressed in the kidney and intestine. Our aim was to characterize homozygous (-/-) and heterozygous (+/-) TRPM6 knockout mice with respect to Mg(2+)...
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