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Article

Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7.

The Journal of general physiology - 1 May 2006

Li Mingjiang, Jiang Jianmin, Yue Lixia

Abstract excerpt

TRPM6 and TRPM7 are two known channel kinases that play important roles in various physiological processes, including Mg2+ homeostasis. Mutations in TRPM6 cause hereditary hypomagnesemia and secondary hypocalcemia (HSH). However, whether TRPM6 encodes functional channels is controversial. Here we demonstrate several signature features of TRPM6 that distinguish TRPM6 from TRPM7 and TRPM6/7 channels. We show that...

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Source

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Identifiers

PMID: 16636202
DOI: 10.1085/jgp.200609502
PMCID: PMC2151519

Genes

TRPM6
TRPM7

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

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Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7.PMID 16636202Read ↗

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Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family.Semantic proximity Read ↗

Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia.Semantic proximity Read ↗

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