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Article

Structural and mutational insights define ERMA as the ER Mg2+ ATPase and reservoir gatekeeper.

Science advances - 3 Jul 2026

Venkatesan Manigandan, Oldham Michael L, Shi Ning, Chidambaram Adhishree, Vishnu Neelanjan, Madesh Abitha K, Bentz Kristen, Stathopulos Peter B, Kalathur Ravi C, Jiang Youxing, Madesh Muniswamy

Abstract excerpt

Magnesium (Mg2+) is the most abundant divalent cation in cells, yet the mechanisms mediating its organellar transport remain poorly defined. We identify endoplasmic reticulum (ER) Mg2+ adenosine triphosphatase (ATPase) (ERMA) as the transporter that drives Mg2+ uptake into the ER lumen, establishing the ER as a bi-ionic intracellular reservoir. MagFRET biosensors targeted to the ER demonstrate that ERMA mediates...

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Identifiers

PMID: 42384784
DOI: 10.1126/sciadv.aef4971
PMCID: PMC13322241

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