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Article

Elucidating molecular phenotypes caused by the SORL1 Alzheimer's disease genetic risk factor using human induced pluripotent stem cells.

Cell stem cell - 2 Apr 2015

Young Jessica E, Boulanger-Weill Jonathan, Williams Daniel A, Woodruff Grace, Buen Floyd, Revilla Arra C, Herrera Cheryl, Israel Mason A, Yuan Shauna H, Edland Steven D, Goldstein Lawrence S B

Abstract excerpt

Predisposition to sporadic Alzheimer's disease (SAD) involves interactions between a person's unique combination of genetic variants and the environment. The molecular effect of these variants may be subtle and difficult to analyze with standard in vitro or in vivo models. Here we used hIPSCs to examine genetic variation in the SORL1 gene and possible contributions to SAD-related phenotypes in human neurons. We...

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Source

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Identifiers

PMID: 25772071
DOI: 10.1016/j.stem.2015.02.004
PMCID: PMC4388804

Genes

SORL1
BDNF
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Elucidating molecular phenotypes caused by the SORL1 Alzheimer's disease genetic risk factor using human induced pluripotent stem cells.PMID 25772071Read ↗

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