Article

A Study of the SORL1 Gene in the Pathogenesis of Late-onset Alzheimer’s Disease by Affecting the Expression of BDNF

2021-07-28

Abstract excerpt

<title>Abstract</title> <p>BackgroundAlzheimer’s disease is a neurodegenerative disease characterized by progressive memory impairment and other cognitive disorders. It is divided into Familial Alzheimer's disease (FAD) and Sporadic Alzheimer's disease (SAD). SAD is also called delayed Late-onset Alzheimer's disease (LOAD). Sortilin Related Receptor 1 (SORL1) is a high-risk pathogenic gene of LOAD, which can part...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0f5a4e5e-f265-5a4e-8636-e76fd7fad475
DOI: 10.21203/rs.3.rs-750372/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Study of the SORL1 Gene in the Pathogenesis of Late-onset Alzheimer’s Disease by Affecting the Expression of BDNFDOI 10.21203/rs.3.rs-750372/v1Read

The Role of SORL1 in Alzheimer’s DiseaseSemantic proximity Read

The neuronal sortilin-related receptor gene SORL1 and late-onset Alzheimer's disease.Semantic proximity Read

Cell-type-specific regulation of APOE levels in human neurons by the Alzheimer’s disease risk gene SORL1Semantic proximity Read

An updated meta-analysis of the association between SORL1 variants and the risk for sporadic Alzheimer's disease.Semantic proximity Read

The Alzheimer’s gene <i>SORL1</i> is a regulator of endosomal traffic and recycling in human neuronsSemantic proximity Read

SORL1 mutations in early- and late-onset Alzheimer diseaseSemantic proximity Read

Identification of two pathogenic mutations in SORL1 in early-onset Alzheimer's disease.Semantic proximity Read

Elucidating molecular phenotypes caused by the SORL1 Alzheimer's disease genetic risk factor using human induced pluripotent stem cells.Semantic proximity Read

Meta-analysis of the association between variants in SORL1 and Alzheimer disease.Semantic proximity Read

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.Semantic proximity Read

SORL1 Is Associated with the Risk of Late-Onset Alzheimer's Disease: a Replication Study and Meta-Analyses.Semantic proximity Read

[A rare variant in the sortilin-related receptor 1 gene is associated with declined cognitive functions in the elderly].Semantic proximity Read