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Article

Genetic epistasis regulates amyloid deposition in resilient aging.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Oct 2017

Felsky Daniel, Xu Jishu, Chibnik Lori B, Schneider Julie A, Knight Jo, Kennedy James L, Bennett David A, De Jager Philip L, Voineskos Aristotle N

Abstract excerpt

INTRODUCTION: The brain-derived neurotrophic factor (BDNF) interacts with important genetic Alzheimer's disease (AD) risk factors. Specifically, variants within the SORL1 gene determine BDNF's ability to reduce amyloid β (Aβ) in vitro. We sought to test whether functional BDNF variation interacts with SORL1 genotypes to influence expression and downstream AD-related processes in humans. METHODS: We analyzed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28322202
DOI: 10.1016/j.jalz.2017.01.027
PMCID: PMC5601013

Genes

BDNF
SORL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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