Article
Influence of genetic variants in SORL1 gene on the manifestation of Alzheimer's disease.
Neurobiology of aging - 1 Mar 2015
Louwersheimer Eva, Ramirez Alfredo, Cruchaga Carlos, Becker Tim, Kornhuber Johannes, Peters Oliver, Heilmann Stefanie, Wiltfang Jens, Jessen Frank, Visser Pieter Jelle, Scheltens Philip, Pijnenburg Yolande A L, Teunissen Charlotte E, Barkhof Frederik, van Swieten John C, Holstege Henne, Van der Flier Wiesje M
Abstract excerpt
We studied the association of SORL1 single-nucleotide polymorphisms genotypes with measures of pathology in patients with probable Alzheimer's disease (AD) using an endophenotype approach. We included (1) 133 patients from the German Dementia Competence Network (71 ± 8 years; 50% females; Mini Mental State Examination [MMSE], 24 ± 3); (2) 83 patients from the Alzheimer's Disease Neuroimaging Initiative (75 ± 8...
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